Process Research & Development

Our Process Research and Development (R&D) function is the foundation of our innovation, scale-up success, and sustainable growth. Backed by experienced scientists and modern laboratory infrastructure, our R&D capabilities support end-to-end API and intermediate development—from early route scouting to commercial manufacturing.

Core R&D Capabilities

• Route Scouting & Process Development: Identification and optimization of synthetic routes focused on yield improvement, impurity control, cost efficiency, and scalability.
• Process Optimization & Cost Improvement: Continuous improvement through solvent optimization, catalyst selection, cycle-time reduction, and raw material efficiency.
• Impurity Profiling & Control: Identification, characterization, and control of process- and degradation-related impurities to meet regulatory and quality requirements.
• Scalability & Technology Transfer: Robust process development enabling seamless transfer from bench scale to kilo lab, pilot plant, and commercial manufacturing.
• Process Safety & Risk Assessment: Evaluation of reaction hazards, thermal behavior, and operability for safe and reliable scale-up.
• Green Chemistry & Sustainability: Environmentally responsible practices including solvent recovery, waste minimization, and energy-efficient processes.

Integrated Development to Manufacturing Support

Our R&D laboratories work closely with pilot plant and manufacturing teams, ensuring seamless knowledge transfer, reduced development risks, faster timelines, and consistent product quality at all scales.

Chemical Reaction Expertise

Our teams possess extensive expertise across a wide range of chemical reactions, enabling efficient development and scale-up of both standard and complex API processes.

Reaction Capabilities

• Carbon–Carbon Bond Formation: Aldol condensation, Knoevenagel condensation, Perkin reaction, Friedel–Crafts reactions
• Functional Group Transformations: Oxidation (including Sarett oxidation), Reduction (including hydrogenation), Halogenation, Formylation
• Substitution & Rearrangement: Sandmeyer reaction, Beckmann rearrangement, Curtius rearrangement, Leuckart–Wallach reaction, Clarke–Eschweiler reductive alkylation
• Condensation & Cyclization: Acetal formation, Schiff base reaction, Pinner synthesis, Cyclization reactions
• Esterification & Related Reactions: Esterification / trans-esterification, Dehydration, Decarboxylation and high-temperature decarboxylation
• Advanced & Specialized Reactions: Cryogenic reactions, Enzymatic reactions, Multi-stage synthesis, Potent and controlled chemistry under flexible containment

Value Delivered Through R&D

• Faster and safer scale-up from development to commercialization
• Robust, regulatory-ready processes
• Cost-effective and sustainable manufacturing solutions
• Consistent quality and long-term supply reliability

Bench Scale to Commercial Manufacturing

Our development and manufacturing model follows a structured and seamless progression from bench-scale research through kilo lab and pilot-scale validation to full commercial production. Each stage is designed to ensure technical robustness, regulatory compliance, cost efficiency, and minimized scale-up risk.

At the bench scale, our R&D teams focus on route scouting, reaction feasibility, impurity profiling, and preliminary process optimization. Proven processes advance to the kilo lab and cGMP-compliant pilot plant, where critical parameters are validated, safety and operability assessments are conducted, and scalability is confirmed.

Successfully validated pilot-scale processes are then transferred to commercial manufacturing, supported by validated procedures, optimized yields, and consistent quality performance. This integrated approach ensures smooth technology transfer, accelerated scale-up, and a reliable supply chain.

Bench Scale (R&D / Lab Scale)

Objective: Process discovery and feasibility

• Route scouting and reaction screening
• Optimization of reaction conditions
• Preliminary impurity profiling
• Small-quantity synthesis for proof of concept
• Initial safety and risk assessment

Kilo Lab (Intermediate Scale)

Objective: De-risk scale-up and enable technology transfer

• First execution of processes at kilogram scale
• Equipment and workflows aligned with pilot and commercial manufacturing
• Validation of process reproducibility and impurity control
• Material generation for toxicology studies and Phase I clinical trials
• Identification and resolution of scale-related challenges
• Scale-down troubleshooting when required

Pilot Plant (Pre-Commercial Scale)

Objective: Process validation and manufacturing readiness

• cGMP-compliant multi-purpose pilot plant operations
• Optimization of yields, cycle times, and cost efficiency
• Process safety evaluation, hazard analysis, and robustness testing
• Finalization of technology transfer
• Preparation of validation and regulatory documentation

Commercial Manufacturing (Full Scale)

Objective: Reliable and compliant product supply

• cGMP-compliant large-scale API manufacturing
• Multi-stage synthesis with continuous improvement
• Consistent quality, impurity control, and batch-to-batch reproducibility
• Regulatory-compliant commercial supply
• Long-term manufacturing and product lifecycle support

Custom Synthesis

We provide tailored synthesis solutions customized to meet diverse customer-specific chemical, quality, and regulatory requirements. Our flexible approach ensures efficient development, reliable scale-up, and compliant manufacturing, supporting both early-stage research and commercial production while aligning with global regulatory expectations and customer objectives.

Analytical Development

Advanced analytical development capabilities ensure product quality, regulatory compliance, and process consistency. Our expertise includes method development, validation, impurity profiling, and stability studies, enabling reliable decision-making, robust process control, and seamless support from research through commercial manufacturing stages.

Quality & Compliance

Our robust quality systems are aligned with international regulatory standards, ensuring consistent product quality, data integrity, and compliance across all stages of development and manufacturing. We follow globally accepted guidelines to meet customer, regulatory, and market expectations with reliability and transparency.

Sustainable Chemistry

Sustainable Chemistry emphasizes designing chemical processes that minimize environmental impact. It prioritizes green methods, reducing hazardous waste, conserving energy and resources, and promoting renewable materials. By integrating eco-friendly practices throughout research, production, and operations, it ensures chemical innovations are safe, efficient, and aligned with environmental responsibility for a sustainable future.